S18 Pharmacogenetics to drive breast cancer treatments
نویسندگان
چکیده
منابع مشابه
Pharmacogenetics of breast cancer therapies.
Treatment decisions for breast cancer patients are currently based on a small number of crude predictive markers, despite the known complexity and heterogeneity of the disease. The field of pharmacogenetics can increase the precision with which therapeutic decisions are made. Discovering associations between genetic variation and treatment response will allow clinicians to tailor therapies to m...
متن کاملPharmacogenetics in breast cancer therapy.
Interindividual and interethnic variability of drug pharmacokinetics and pharmacodynamics may be contributed by commonly occurring genetic polymorphisms of drug-metabolizing enzymes and transporters. Polymorphisms of CYP2D6 in particular have been associated with effects on tamoxifen disposition and clinical efficacy, with interethnic differences in distribution of functional alleles that affec...
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Epithelial cancers including breast and prostate commonly progress to form incurable bone metastases. For this to occur, cancer cells must adapt their phenotype and behaviour to enable detachment from the primary tumour, invasion into the vasculature, and homing to and subsequent colonisation of bone. It is widely accepted that the metastatic process is driven by the transformation of cancer ce...
متن کاملPharmacogenetics of capecitabine in advanced breast cancer patients.
PURPOSE Germinal gene polymorphisms can explain a part of the interpatient pharmacodynamic variability of anticancer drugs, particularly fluoropyrimidines. Genes for which polymorphisms may potentially influence pharmacodynamics of fluoropyrimidines, including capecitabine, are thymidylate synthase (TS), methylenetetrahydrofolate reductase (MTHFR), and dihydropyrimidine dehydrogenase (DPD). E...
متن کاملPharmacogenetics of breast cancer: toward the individualization of therapy.
Why should wait for some days to get or receive the pharmacogenetics of breast cancer towards the individualization of therapy book that you order? Why should you take it if you can get the faster one? You can find the same book that you order right here. This is it the book that you can receive directly after purchasing. This pharmacogenetics of breast cancer towards the individualization of t...
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ژورنال
عنوان ژورنال: The Breast
سال: 2009
ISSN: 0960-9776
DOI: 10.1016/s0960-9776(09)70026-8